5F-AKB48 (also known as 5F-APINACA) is a synthetic cannabinoid substance of the indazolecarboxamide class. It acts as a potent agonist for the CB1 and CB2 cannabinoid receptors

5F-AKB48 has been investigated in the scientific literature. It was first identified in South Korea and is available for sale as a grey area research chemical through online vendors.

Subjective effects are reported to be somewhat similar to that of cannabis with a short duration and an emphasis on intense physical sensations.

Cannabinoids are commonly smoked or vaporized to achieve a quick onset of effects and rapid offset. 5F-AKB48 is orally active when dissolved in a lipid, which can increase the duration significantly. Like other cannabinoids, it is insoluble in water but dissolves in ethanol and lipids. Not for human consumption.

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